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. 2020 May 12;12:3343–3352. doi: 10.2147/CMAR.S250772

Figure 1.

Figure 1

Expression pattern and clinical significance of miR-340 in GBM samples. (A) miR-340 was significantly up-regulated in the Proneural subtype (PN) compared with the other subtypes: Classical (CL), Mesenchymal (ME) and Neural (NE) in TCGA dataset. (B) EMT process associated genes were more enriched in the GBM patients with low expression level of miR-340 via GSEA analysis in TCGA dataset. (C) High level of miR-340 predicts a better prognosis in TCGA GBM patients. (D) The expression level of miR-340 was lower in recurrent GBM than those in primary cases. (E) miR-340 was significantly down-regulated in GBM cells (U87, U251 and LN229 cell lines) compared to normal glial cell line (NHA). * P <0.05, **P<0.01.