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Structural comparison of the S. cerevisiae B-family polymerase Polδ in complex with undamaged DNA (PDB: 3IAY) and the Y-family polymerase Polη in complex with damaged (PDB: 3MFH) and undamaged DNA (3MFI). The Y-family polymerases grasps the DNA (black) less closely than the B-family polymerase, which allows the Y-family polymerase to tolerate damaged DNA and perform TLS.
