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Rev1 and interactions with PCNA. (A) Domains and motifs in human Rev1. (B) Overlay of the structures of human and yeast Rev1-BRCT domain (PDB: 2EBW, 2M2I, 4ID3, 5UMV, 5VX7). (C) Structure of human PCNA (PDB: 1AXC). The interdomain connecting loop (ICL) where the Rev1-BRCT and PIP-box interact is highlighted. (D) NMR structure of the Rev1-UBM2 in complex with ubiquitin (PDB: 6ASR, 6ASD).
