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. 2020 Apr 22;48(9):4709–4724. doi: 10.1093/nar/gkaa248

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© The Author(s) 2020. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — Contributions of different types of hPTM to differentiate developmental gain versus developmental loss over time in (A) forebrain (B) heart (C) hindbrain (D) limb (E) neuraltube (F) liver (G) midbrain. The importance score generated by random forest was normalized so that the maximum value is 1. H3K36me3 is the top predictive feature across all the timepoints and tissues.