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. 2020 Apr 22;48(9):4709–4724. doi: 10.1093/nar/gkaa248

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© The Author(s) 2020. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — Top stable interactions of histone modifications in the exon flanking region for gain versus loss group obtained by iRF algorithm (stability score > = 0.5). 3 tissues (12.5 day) were visualized: (A) forebrain, (B) heart and (C) liver. Many histone modification interactions were observed in forebrain, heart and liver for developmental gain versus loss category at E12.5. These included interactions between modifications on different amino acids (e.g. H3K36me3 and H3K4me1), between different kinds of modifications (e.g. H3K4me1 and H3K9ac), and between the different genic regions of the same histone modification (e.g. H3K4me1 5′ downstream and H3K4me1 3′ upstream).