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. 2020 Apr 22;48(9):4709–4724. doi: 10.1093/nar/gkaa248

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© The Author(s) 2020. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 7. — Potential mechanistic connection between histone modifications and tissue development. (A) Genome browser view shows the enrichment of H3K36me3 and exonN inclusion in forebrain, heart, liver and limb. (B) The inclusion level of exonN in FLNA gene was significantly correlated with H3K36me3 enrichment. (C) Schematic depicts a potential mechanism by which H3K36me3 regulates exonN inclusion. H3K36me3 can recruit splicing factor PTBP1, which will further repress exonN inclusion.