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. 2020 Apr 16;48(9):4877–4890. doi: 10.1093/nar/gkaa234

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© The Author(s) 2020. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — HDAC inhibition up-regulates promoter–proximal paused genes by releasing Pol II into elongation. (A) Mean pausing index (PRO-seq reads from promoter–proximal, −50 to +100-bp region, versus gene body, +500 bp to TES) for unchanged genes (left) and up-regulated genes (right) after 10 min of TSA treatment in DMSO, TSA 10 min and TSA 30 min-treated S2 cells. (B) Correlation between PRO-seq gene body fold change and pausing index in DMSO and TSA 10 min treated cells. (C) Metagene PRO-seq profiles for up-regulated and no change genes after 10 min of TSA. Significant differences between control and TSA-treated cells (two-tailed paired t-test) for the 96 up-regulated genes are indicated. (D) Metagene PRO-seq profiles for down-regulated, up-regulated and no change genes after 30 min of TSA.