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. 2020 Apr 16;48(9):5094–5105. doi: 10.1093/nar/gkaa247

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© The Author(s) 2020. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 6. — m⁶A in box D/D' inhibits activity of Ct C/D RNP. (A) Secondary structure of human U46 snoRNA. Nucleotides 31–69 are deleted in U46-S. The m⁶A site is indicated. (B) Modification activity of Ct RNPs assembled with snR61, U46 and U46-S that contain an m⁶A or unmodified adenine in box D or D'. (C) Quantification of modification. The level of 2′-O-methylation guided by m⁶A-containing C/D RNA is normalized to that guided by unmodified C/D RNAs. The mean and standard deviation determined from three experiments are shown.