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. 2020 Apr 16;48(9):5094–5105. doi: 10.1093/nar/gkaa247

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© The Author(s) 2020. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 7. — Assembly model of eukaryotic C/D RNP. (A) In vitro assembly. Active enzymes can be assembled from single and dual paralog (SP, DP) of Nop56 and Nop58. The SP-RNPs are less active than the DP-RNPs. Due to the lack of binding specificity between the box C/D motifs and Nop56/Nop58 proteins, the C/D RNA adopts both forward and reverse orientations in reconstituted DP-RNPs. (B) In vivo assembly. With assistance of assembly factors, Nop58 and Snu13 are first assembled on box C/D, establishing the asymmetric and specific organization of C/D RNP.