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The representative compounds targeting to hcLRS. (A) The compound name, structure and targeting site are listed; the binding of leucine (B) and leucinol (C) in the aminoacylation active site are generated based on the structure of hcLRS-LeuAMS; (D) The BC-LI-0186 binding site (red color) in the proposed hcLRS-tRNALeu model.
