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. 2020 Mar 30;48(9):4946–4959. doi: 10.1093/nar/gkaa189

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© The Author(s) 2020. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — The inhibition effects of three anti-fungal or anti-bacteria benzoxaborole compounds (tavaborole, AN6426 and ZCL039) to hcLRS. (A) The reaction scheme between tavaborole and A76 of tRNA (or AMP) in LRS editing site; (B) Shows the binding pocket for tavaborole-AMP in TtLRS and the docking model of tavaborole-AMP in hcLRS; (C) The IC₅₀ values of tavaborole, AN6426 and ZCL039 to hcLRS assayed in vitro; The binding of AN6426–AMP in the complex structure of hcLRS–AN6426–AMP in electrostatics surface (D) and in cartoon (F); (E) The density map of AN6426–AMP in the complex structure of hcLRS–AN6426–AMP; (G) The binding pocket for ZCL039-AMP in SpLRS, and the docking model of ZCL039-AMP in hcLRS-CP1 in which the ZCL-039 clashed with hcLRS-CP1.