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. 2020 Apr 6;48(9):5065–5080. doi: 10.1093/nar/gkaa194

Figure 3.

Figure 3.

ASO-29 enhances inner and outer hair cell survival. (A) Representative whole mount Myosin7a (Myo7a) confocal microscopic projections showing enhanced hair cell survival at 1.0, 2.0 and 3.0 mm from the tip of the cochlear apex (8–24 kHz inclusive) in ASO-29-treated mutants at P30. Distance from the apical tip was translated to frequencies using the cochlear place frequency map shown in Supplementary Figure S2A. Scale bar: 20 μm. (B) Quantification of IHCs and OHCs ± SEM 0.5 to 4 mm from the tip of the cochlear apex (8–32 kHz inclusive). Untreated mutants were compared to the two ASO-29 treatment groups by two-way repeated measures ANOVA with Tukey's Multiple Comparison Test: *P < 0.05, **P < 0.01, n = 5 per group. The number of outer hair cells in ASO-29 mutants and ASO-29 heterozygotes was significantly different only at 4 mm by two-way repeated measures ANOVA with Tukey's Multiple Comparison Test: †P < 0.05, n = 5 per group.