Table 1.

Sensitivity and Specificity of Critical Sample Laboratory Values for the Diagnosis of Hyperinsulinism (C. Ferrara, Patel, Becker, Stanley, & Kelly, 2016)

	Sensitivity, %	Specificity, %
DETECTABLE INSULIN	82.2	100
ELEVATED C-PEPTIDE (≥0.5 ng/mL)	88.5	100
SUPPRESSED IGFBP1 (≤ 110 ng/mL)	85	97
SUPPRESSED β-HYDROXYBUTYRATE (<1.8 mM)	100	100
SUPPRESSED FREE FATTY ACIDS (<1.7 mM)	86.9	100
POSITIVE GLYCEMIC RESPONSE TO 1MG GLUCAGON INJECTION (Δ plasma glucose ≥30mg/dL)	88.9	100

IGFBP1: insulin-like growth factor binding protein 1