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. 2019 Aug 10;69(5):911–919. doi: 10.1136/gutjnl-2019-319146

Figure 1.

Figure 1

RM-LNC-mediated glucagon-like peptide-1 (GLP-1) secretion in vitro and in vivo and exenatide plasma levels in normoglycaemic mice. (A) RM-LNC-mediated in vitro GLP-1 secretion (2 mg/mL) in GLUTag (left) and NCI-H716 (right) cells (murine and human L-cells, respectively) after a 2-hour coincubation period (mean±SEM; n=6–10). (B) In vivo total GLP-1 secretion in normoglycaemic mice 60 and 180 min after RM-LNC oral administration (mean±SEM; n=7–8). (C) Exenatide blood profile after oral administration to normoglycaemic mice in solution in water (EXE) or encapsulation within RM-LNC (EXE-RM-LNC) (500 µg/kg exenatide dose) (mean±SEM; n=4). P values in (A, B) were determined by Student’s t test or Mann-Whitney test. Data with different superscript letters (C) are significantly different (p<0.05) according to two-way analysis of variance followed by Tukey’s post hoc test.