Table 4.

The adjusted ORs of immunoprophylaxis failure according to the cut-off values of these quasispecies characteristic in “a” determinant region using NGS assay

Characteristic (level)	Cut-off value	OR (95% CI)	β	SE	P value
Mutant frequency (nt)	0.0002	0.132 (0.029 to 0.594)	−2.022	0.766	0.008
Mutant frequency (aa)	0.0006	0.183 (0.042 to 0.810)	−1.696	0.758	0.025
Shannon entropy (nt)	0.0055	0.132 (0.029 to 0.594)	−2.022	0.766	0.008
Shannon entropy (aa)	0.0055	0.183 (0.042 to 0.810)	−1.696	0.758	0.025
Genetic distance (nt)	0.014	0.132 (0.029 to 0.594)	−2.022	0.766	0.008
Genetic distance (aa)	0.014	0.183 (0.042 to 0.810)	−1.696	0.758	0.025

β, regression coefficient; aa, amino acid; NGS, next-generation sequencing; nt, nucleotide.