Table 1.

Pupil metrics. Key. s: seconds; PIPR: post illumination pupil response; AUC: area under the curve.

Metric	Calculation
Baseline pupil diameter	Average pupil diameter 10 s prior to light stimulation
Maximum constriction	Minimum pupil diameter during light stimulation
6 s PIPR	Pupil diameter averaged over 6–7 s after stimulus offset, relative to the baseline pupil diameter
30 s PIPR	Pupil diameter averaged over 30–31 s after stimulus offset, relative to the baseline pupil diameter
AUC	Trapezoidal sum of the interpolated normalised trace for 20 s after light offset