Figure 2. Overview of all reported Polθ activities.

Representation of the various activities that are carried out by Polθ. The major and well-established Polθ function is during DSB repair by MMEJ and has been studied using different substrates and in various model systems (green). Polθ has also been linked to the repair of breaks associated with replication forks (yellow). Lastly, Polθ employs its translesion synthesis activity to bypass UV-damaged bases and abasic sites (orange).