Table 2.
Unadjusted outcome and risk factors
| Group of patients | N | OS, median [months] | 4YS [%] | 5YS [%] | Logrank p-value |
|---|---|---|---|---|---|
| Total | 1033 | 30.3 | 30.4 | 22 | |
| 1990–1994 | 279 | 24.2 | 22.6 | 14 | < 0.0001 |
| 1995–1999 | 408 | 29.6 | 29.7 | 23 | |
| 2000–2004 | 143 | 36.5 | 36.4 | 30.8 | |
| 2005–2009 | 203 | 37.8 | 37.4 | 24.6 | |
| Bone only | 215 | 44.8 | 48.8 | 36.7 | < 0.0001 |
| Liver and/or lung | 608 | 24.7 | 23.5 | 16.5 | |
| Other | 210 | 31.8 | 29.1 | 21 | |
| HR + | 613 | 37.3 | 36.4 | 25.9 | < 0.0001 |
| HR − | 307 | 19.7 | 14.3 | 10.1 | |
| HR unknown | 113 | 31.1 | 37.2 | 29.2 | |
| Initial metastasis | 126 | 38.6 | 38.1 | 29.4 | < 0.0001 |
| DFI < 18 month | 210 | 18.4 | 17.1 | 11.4 | |
| DFI 18–35 month | 226 | 25.4 | 21.7 | 15 | |
| DFI > 35 month | 471 | 37.5 | 37.4 | 27.2 | |
| Age < 50 years | 421 | 29.6 | 28.7 | 20.9 | 0.6087 |
| Age ≥ 50 years | 612 | 31.6 | 30.7 | 22.1 |
Median overall survival, probability of 4-year and 5-year overall survival of patients with metastatic breast cancer, according to time period of diagnosis of metastatic disease and according to prognostic factors
OS overall survival. 4YS, 4-year overall survival. 5YS 5-year overall survival