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. Author manuscript; available in PMC: 2021 Jun 1.
Published in final edited form as: Trends Biochem Sci. 2020 Mar 21;45(6):472–483. doi: 10.1016/j.tibs.2020.02.010

Figure 5. Examples of Intervention with Mesoscale Assemblies.

Figure 5.

(Left) Treatment of HIV-1 with allosteric integrase inhibitors (ALLINIs) cause integrase (red) to aggregate and has the surprising mesoscale effect of corrupting the process of encapsidation of the viral RNA (yellow). (Right) Chimeric antigen receptors (red) recruit macrophages (left half of the image) to target cells (right half of the image), releasing perforins (magenta) and leading to destruction of the target. Illustrations from the HIVE Center and RCSB Protein Data Bank.