Table 5.
Specific bacterial taxa associated with level of urinary Pb concentration, adjusted for covariates.
| Uncorrected P-value | Direction | |||
|---|---|---|---|---|
|
|
||||
| Two-part | Zero-part | Positive-part | ||
|
| ||||
| Phylum | ||||
| Proteobacteria | 0.0236 | 0.0006* | 0.9620 | ↑ |
| Class | ||||
| Alphaproteobacteria | 0.6436 | 0.0198 | 0.6436 | ↑ |
| Betaproteobacteria | 0.5050 | 0.0099 | 0.5050 | ↑ |
| Deltaproteobacteria | 0.0119 | 0.0119 | 1.0000 | ↑ |
| Gammaproteobacteria | 0.0317 | 0.7030 | 0.0307 | ↑ |
| Order | ||||
| Burkholderiales | 0.0044 | 0.0002* | 0.7822 | ↑ |
| Clostridiales | 0.0008 | 0.1582 | 0.0008 | ↓ |
| Desulfovibrionales | 0.0921 | 0.0277 | 0.8208 | ↑ |
| Rhizobiales | 0.1683 | 0.0099 | 0.1683 | ↑ |
| Family | ||||
| Alcaligenaceae | 0.4356 | 0.0099 | 0.4356 | ↑ |
| Barnesiellaceae | 0.2574 | 0.0495 | 0.2574 | ↑ |
| Brucellaceae | 0.0248 | 0.0248 | 1.0000 | ↑ |
| Clostridiaceae | 0.0218 | 0.0406 | 0.1416 | ↓ |
| Desulfovibrionaceae | 0.0644 | 0.0178 | 0.4772 | ↑ |
| Enterococcaceae | 0.0129 | 0.9307 | 0.0129 | ↑ |
| Lactobacillaceae | 0.1881 | 0.0396 | 0.5446 | ↓ |
| Oxalobacteraceae | 0.3267 | 0.0495 | 0.3267 | ↑ |
| Rikenellaceae | 0.0584 | 0.0208 | 1.0000 | ↑ |
| Genus | ||||
| Clostridium | 0.0455 | 0.7406 | 0.0455 | ↓ |
| Coprococcus | 0.0238 | 0.0099 | 0.3178 | ↓ |
| Desulfovibrio | 0.8119 | 0.0396 | 0.8119 | ↑ |
| Eubacterium | 0.0149 | 0.0525 | 0.0663 | ↑ |
| Pediococcus | 0.0124 | 0.0124 | 1.0000 | ↓ |
| Ruminococcus | 0.0208 | 0.0614 | 0.0347 | ↑ |
Data come from the microbiome study sample of the Survey of the Health of Wisconsin 2016–2017.
Analysis was performed using Quasi Conditional Association Test using Generalized Estimating Equations (QCAT-GEE), adjusted for age, gender, body mass index, antibiotic use, race/ethnicity, education, smoking, fiber consumption, urbanicity, and indoor pets.
*
Indicates p < 0.05 after FDR correction.