Table 1.

Representative heart genes regulated by RBM20 and PTBP1.

Gene Symbola	Gene Name	Regulated Exons	Species	References
RBM20-regulated genes
CACNA1C	Calcium Voltage-Gated Channel Subunit α1 C	9	Human ESC RBM20 KO CMs	[88]
		9*	Rat cardiomyocytes	[89]
CAMK2D	Calcium/calmodulin dependent protein kinase II delta	14	Human cardiac RBM20 (S635A) tissue, Rbm20-/- rats, Human ESC RBM20 KO CMs	[33]
CAMKIIG	Calcium/calmodulin dependent protein kinase II gamma	12–15	Human cardiac RBM20 (S635A) tissue, Rbm20-/- rats	[33]
FHOD3	Formin homology 2 domain containing 3	12–14	HeLa cells	[32]
LDB3	LIM domain binding 3	4, 5/6	Human cardiac RBM20 (S635A) tissue, Rbm20-/- rats	[33]
LMO7	LIM domain only protein 7	9, 10	Rbm20-/- rats	[38]
MLIP	Muscular-enriched A type laminin-interacting protein	9, 10	Rbm20-/- rats	[38]
PDLIM3	PDZ and LIM domain 3	4–6	Rbm20-/- rats	[38]
RTN4	Reticulon 4	3, 4	Rbm20-/- rats	[38]
RYR2	Ryanodine receptor 2	24 bp exon	Rbm20-/- rats	[38]
SH3KBP1	SH3 domain containing kinase binding protein 1	6–7	Human cardiac RBM20 (S635A) tissue, Rbm20-/- rats	[33]
SORBS1	Sorbin and SH3 domain containing 1	2	Human cardiac RBM20 (S635A) tissue, Rbm20-/- rats	[33]
TRDN	Triadin	8	Human cardiac RBM20 (S635A) tissue, Rbm20-/- rats	[33]
TTN	Titin	PEVK exons	Human cardiac RBM20 (S635A) tissue, Rbm20-/- rats, Human ESC RBM20 KO CMs	[33,88]
PTBP1-regulated genes
ACTN1	α-actinin	NM/SM	Non-smooth muscle cells, PAC1 smooth muscle cells	[90,91]
CACNA1C	Calcium Voltage-Gated Channel Subunit α1 C	8/8a	Neuro-2a cells	[92]
FHOD3	Formin homology 2 domain containing 3	12–14	HeLa cells	[32]
MEF2	Myocyte Enhancer Factor 2	3	Rat cardiomyocytes	[93]
TNNT2	Troponin T type 2	5	Primary embryonic skeletal muscle cultures	[94]
TPM1	Tropomyosin 1	3	PAC1 smooth muscle cells	[91,95]
		9	Rat cardiomyocytes	[93]
TPM2	Tropomyosin 2	7	HeLa cells, rat cardiomyocytes	[93,96]
TTN	Titin	242	HEK293 cells	[31]

^a Genes underlined are commonly regulated by RBM20 and PTBP1. CM: cardiomyocytes; ESC: embryonic stem cell.