Table 2.
Gene | n (%) | MAF (%) (n = 53) |
MAF CEU * | HWE p |
Trough Plasma Levels Median (range) |
p ** | Peak Plasma Levels Median (range) |
p ** | ||
---|---|---|---|---|---|---|---|---|---|---|
ABCB1 | rs1045642 | CC | 14 (26.4%) | 48.11 | 43.4 | 0.98 | 139.4 (99.3; 187.5) | 0.6 | 231.5 (176; 438.7) | 0.8 |
C > T | CT | 27 (50.9%) | 132.1 (87.1; 238.3) | 293.5 (219.6; 370.1) | ||||||
TT | 12 (22.6%) | 128 (80.1; 179.5) | 305.1 (142.1; 393.2) | |||||||
rs4148738 | GG | 15 (28.3%) | 46.22 | 46.0 | 0.85 | 166.5 (99.5; 206.8) | 0.5 | 271.4 (198.1; 442.7) | 0.9 | |
G > A | GA | 27 (50.9%) | 127.4 (70.5; 194.7) | 281.2 (205.6; 346.4) | ||||||
AA | 11 (20.8%) | 128 (87.3; 195) | 305.1 (144.7; 393.2) |
SNP single nucleotide polymorphism; MAF minor allele frequency; HWE Hardy–Weinberg equilibrium; MAF CEU *—Utah residence with northern and western European ancestry [22]; p **—Kruskal–Wallis test.