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. 2020 Apr 17;11(4):438. doi: 10.3390/genes11040438

Table 2.

Distribution of ABCB1 genotype and allele frequencies.

Gene n (%) MAF (%)
(n = 53)
MAF CEU * HWE
p
Trough Plasma Levels
Median (range)
p ** Peak Plasma Levels
Median (range)
p **
ABCB1 rs1045642 CC 14 (26.4%) 48.11 43.4 0.98 139.4 (99.3; 187.5) 0.6 231.5 (176; 438.7) 0.8
C > T CT 27 (50.9%) 132.1 (87.1; 238.3) 293.5 (219.6; 370.1)
TT 12 (22.6%) 128 (80.1; 179.5) 305.1 (142.1; 393.2)
rs4148738 GG 15 (28.3%) 46.22 46.0 0.85 166.5 (99.5; 206.8) 0.5 271.4 (198.1; 442.7) 0.9
G > A GA 27 (50.9%) 127.4 (70.5; 194.7) 281.2 (205.6; 346.4)
AA 11 (20.8%) 128 (87.3; 195) 305.1 (144.7; 393.2)

SNP single nucleotide polymorphism; MAF minor allele frequency; HWE Hardy–Weinberg equilibrium; MAF CEU *—Utah residence with northern and western European ancestry [22]; p **—Kruskal–Wallis test.