Table 5.
Doppler based resistive index and hemodynamic parameters.
| Global Cohort | AKI SCyC | No AKI SCyC | p-Value | |
|---|---|---|---|---|
| n = 100 | n = 10 | n = 90 | ||
| Renal Doppler based parameters | ||||
| Peak systolic velocity—cm/s ± SD | ||||
| Baseline | 29.2 ± 9.5 | 28.9 ± 7.7 | 29.3 ± 9.7 | 0.91 |
| Post TAVR—Day 1 | 32.5 ± 11 | 33.7 ± 6.9 | 32.4 ± 11.4 | 0.72 |
| Post TAVR—Day 3 | 31.2 ± 8.7 | 26.7 ± 8.6 | 31.7 ± 8.6 | 0.083 |
| End diastolic velocity—cm/s ± SD | ||||
| Baseline | 6.8 ± 2.1 | 6.3 ± 1.4 | 6.8 ± 2.2 | 0.47 |
| Post TAVR—Day 1 | 7 ± 3.3 | 5.7 ± 1.5 | 7.2 ± 3.4 | 0.17 |
| Post TAVR—Day 3 | 6.9 ± 2.8 | 6.9 ± 4 | 6.9 ± 2.6 | 0.98 |
| Renal doppler resistive index (RRI) | ||||
| Baseline | 0.76 ± 0.7 | 0.78 ± 0.4 | 0.75 ± 0.7 | 0.34 |
| Post TAVR—Day 1 | 0.78 ± 0.6 | 0.83 ± 0.1 | 0.77 ± 0.6 | 0.005 |
| Post TAVR—Day 3 | 0.77 ± 0.6 | 0.75 ± 0.1 | 0.78 ± 0.5 | 0.11 |
| RRI Day 1 > 0.7 (no./total no. (%)) | 90 (90%) | 10 (100%) | 80 (80%) | 0.37 |
| RRI Day 1 > 0.8 (no./total no. (%)) | 42 (42%) | 8 (80%) | 34 (37.8%) | 0.013 |
| RRI Day 3 > 0.7 (no./total no. (%)) | 93 (93%) | 8 (80%) | 85 (94.4%) | 0.14 |
| RRI Day 3 > 0.8 (no./total no. (%)) | 40 (40%) | 4 (40%) | 36 (40%) | 0.64 |
| Echocardiography | ||||
| Mean Aortic Gradient—mmHg ± SD | ||||
| Baseline | 44.5 ± 11.9 | 43.5 ± 9.8 | 44.6 ± 12.2 | 0.72 |
| Post TAVR—Day 1 | 8.4 ± 2.6 | 7.9 ± 3.5 | 8.5 ± 3.6 | 0.64 |
| Post TAVR—Day 3 | 9.4 ± 4.2 | 9.9 ± 5 | 9.4 ± 4.1 | 0.71 |
| Stroke volume—mL ± median IQR | ||||
| Baseline | 81.5 (65.2–99.5) | 92.5 (63–106.2) | 80 (65.7–98.5) | 0.34 |
| Post TAVR—Day 1 | 75 (64.5–89.7) | 78 (55–97) | 75 (65.5–89) | 0.87 |
| Post TAVR—Day 3 | 78.5 (64.2–90.7) | 84.5 (64.5–104.7) | 77.5 (64–90.3) | 0.5 |
| Cardiac index—mL/min/m2 | ||||
| Baseline | 2.9 ± 0.9 | 3.3 ± 1.3 | 2.8 ± 0.9 | 0.17 |
| Post TAVR—Day 1 | 2.9 ± 0.9 | 3 ± 0.8 | 2.9 ± 0.9 | 0.86 |
| Post TAVR—Day 3 | 2.9 ± 0.98 | 3 ± 1.2 | 2.9 ± 0.96 | 0.59 |
| E/A | ||||
| Baseline | 0.9 ± 0.6 | 0.6 ± 0.2 | 1 ± 0.6 | 0.95 |
| Post TAVR—Day 1 | 0.9 ± 0.5 | 0.95 ± 0.6 | 0.9 ± 0.5 | 0.85 |
| Post TAVR—Day 3 | 1.4 ± 2.6 | 0.7 ± 0.1 | 1.5 ± 2.8 | 0.53 |
| E/e′ | ||||
| Baseline | 11.9 ± 4.6 | 12.9 ± 3.9 | 11.7 ± 4.6 | 0.48 |
| Post TAVR—Day 3 | 10.4 ± 3.8 | 11.9 ± 3.6 | 10.2 ± 3.8 | 0.21 |
| Post TAVR—Day 3 | 11.2 ± 4.3 | 11.7 ± 1.8 | 11.1 ± 4.6 | 0.69 |
| Right Atrial Pressure—mmHg ± SD | ||||
| Baseline | 7 ± 4 | 10 ± 6 | 6 ± 4 | 0.02 |
| Post TAVR—Day 1 | 6.5 ± 3 | 8 ± 4 | 6 ± 3 | 0.09 |
| Post TAVR—Day 3 | 7 ± 4 | 9 ± 6 | 7 ± 4 | 0.31 |
Data are presented as mean ± or n (%) or median (25th–75th percentile). AKI = acute kidney injury; RAP = right atrial pressure; RRI = renal resistive index; SV = stroke volume; sCyC = serum Cystatin C; TAVR = Transcatheter aortic valve replacement.