Table 6.
Biosensors | Advantages | Limitations | Reference |
---|---|---|---|
Impedimetric | High sensitivity and selectivity, time-efficient, simple operation, fast response, mobility due to portable instrumentation, miniaturization |
Complex construction, expensive labeling markers | [25,124,147] |
Potentiometric | Reduced analysis time, mobility due to portable instrumentation, miniaturization, high sensitivity and selectivity, use without sample treatment | The sensitivity and lifetime are seriously influenced by factors such as temperature, pH, immobilization support, and immunological cross-reaction | [129,147,148] |
Amperometric | Mobility due to portable instrumentation, miniaturization, high sensitivity and selectivity | Regeneration between measurements | [147] |
Surface plasmon resonance | High specificity and sensitivity, small size and cost-efficiency, direct, real-time analysis and detection without label, development of portable devices | The broad practical application is still under development | [25,144] |
Quartz crystal microbalance | Low cost with high sensitivity, selectivity, and possibility of reuse, real-time output, and label- or radiation-free entities, development of portable devices | Requirement of a relatively high background signal relative to the signal-on assay formation | [119,149] |