Table 2.

Group 1: performance of the quick sepsis-related organ failure assessment (qSOFA), Model 1, Model 2, and Model 3.

	AUROC	Sensitivity	Specificity	NPV	PPV	LR-	LR+
SOFA	0.65	0.70	0.53	0.83	0.25	0.51	1.57
(cut-off 3)	(0.61–0.69)	(0.61–0.78)	(0.50–0.58)	(0.81–0.91)	(0.23–0.33)	(0.39–0.67)	(1.36–1.79)
qSOFA	0.67	0.46	0.82	0.84	0.36	0.66	2.58
(cut-off 2)	(0.62–0.72)	(0.38–0.54)	(0.79–0.85)	(0.82–0.90)	(0.32–0.44)	(0.56–0.77)	(2.03–3.28)
eqSOFA1a	0.79	0.79	0.68	0.94	0.35	0.31	2.43
(cut-off* 0.16)	(0.75–0.83)	(0.72–0.86)	(0.63–0.71)	(0.91–0.97)	(0.31–0.45)	(0.23-0.43)	(2.12–2.79)
eqSOFA1+CRP+lactateb	0.81	0.81	0.67	0.94	0.36	0.24	2.55
(cut-off* 0.15)	(0.78–0.85)	(0.77–0.89)	(0.64–0.71)	(0.90–0.96)	(0.32–0.47)	(0.17–0.35)	(2.25–2.91)
eqSOFA1+CRP+lactate+MR-proADMc	0.83	0.82	0.75	0.94	0.40	0.30	3.09
(cut-off* 0.18)	(0.80–0.87)	(0.70–0.84)	(0.71–0.78)	(0.92–0.96)	(0.36–0.51)	(0.22–0.40)	(2.64–3.61)

Abbreviations: SOFA= sequential organ failure assessment, eqSOFA₁= “extended” quick sepsis-related organ failure assessment derived in Group 1, CRP= C-reactive protein, MR-proADM= mid-regional proadrenomedullin, AUROC= area under the receiver operating characteristic curve, NPV=negative predictive value, PPV=positive predictive value, LR-=negative likelihood ratio, and LR+=positive likelihood ratio. ()=95% Confidence Interval. ^aModel 1: gender, age, Charlson Index score, qSOFA score, body temperature <36°C, heart rate >90/minute, and white blood cell>12,000/mm³. ^bModel 2: gender, age, Charlson Index score, qSOFA score, body temperature <36°C, heart rate >90/minute, white blood cell>12,000/mm³, Log C-reactive protein, and Log lactate. ^cModel 3: gender, age, Charlson Index score, qSOFA score, body temperature <36°C, heart rate >90/minute, white blood cell>12,000/mm³, Log C-reactive protein, Log lactate, and Log mid-regional proadrenomedullin *Cut-off of the models were selected according to the Youden Index method.