Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Apr 17;11(4):440. doi: 10.3390/genes11040440

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Screen and validation of intersection genes. (a) Validation of ACOX1, ALDH2, FUT6, and LRRC19 differential expression in KICR on GEPIA2. Box plots show that there was a significant differential expression of LRRC19 between KIRC cases and normal cases (| ${log}_{2} F C$ | > 1 and p < 0.05). (b) Stage plots of intersection genes expression with tumor stage in KICR on GEPIA2. Violin plots show ACOX1, FUT6, and LRRC19 were significantly downregulated in Stage IV (p < 0.001). (c) Kaplan–Meier plots show the prognostic value of ACOX1, ALDH2, FUT6, and LRRC19. Overall and disease-free survival curves were generated for the comparison of survival percent between groups with high and low gene expression (p < 0.01 in Log-rank test). (d) Validation of DIO1, GPX3, and LRRC19 expression fold change in independent GEO cohorts, GSE781 and GSE6344. (e) Multivariate analysis of the correlation of LRRC19 expression with OS among KIRC patients. The columns in the forest plot are parameter, number of patients, HR (IC 95%), and p value. (* p < 0.05, ** p < 0.01, *** p < 0.001).

Screen and validation of intersection genes. (a) Validation of ACOX1, ALDH2, FUT6, and LRRC19 differential expression in KICR on GEPIA2. Box plots show that there was a significant differential expression of LRRC19 between KIRC cases and normal cases (| ${log}_{2} F C$ | > 1 and p < 0.05). (b) Stage plots of intersection genes expression with tumor stage in KICR on GEPIA2. Violin plots show ACOX1, FUT6, and LRRC19 were significantly downregulated in Stage IV (p < 0.001). (c) Kaplan–Meier plots show the prognostic value of ACOX1, ALDH2, FUT6, and LRRC19. Overall and disease-free survival curves were generated for the comparison of survival percent between groups with high and low gene expression (p < 0.01 in Log-rank test). (d) Validation of DIO1, GPX3, and LRRC19 expression fold change in independent GEO cohorts, GSE781 and GSE6344. (e) Multivariate analysis of the correlation of LRRC19 expression with OS among KIRC patients. The columns in the forest plot are parameter, number of patients, HR (IC 95%), and p value. (* p < 0.05, ** p < 0.01, *** p < 0.001).