Table 2.
Pharmacokinetic parameters for linezolid. Entries are the median [interquartile range], estimate (95% confidence interval), or count (%). The p-values refer to comparisons of the obese and non-obese groups. AUC = area under the concentration–time curve; CL = total body clearance; ISF = interstitial fluid of the subcutaneous adipose tissue; MRT = mean resistance time; Vss = volume of distribution at a steady state; Cmax = maximum concentration; t1/2 = half-life; Tmax = time point of Cmax. Bold type indicates significant values.
| All Patients (n = 30) |
Pearson’s Correlation Coefficient with Weight | Obese (n = 15) |
Non-Obese (n = 15) |
p-Value | |
|---|---|---|---|---|---|
| Cmax (mg/L) | |||||
| ISF | 5.5 [3.8, 8.5] | −0.70 (−0.85 to −0.45) | 3.8 [3.2, 5.3] | 8.3 [5.7, 10.2] | <0.001 |
| Plasma (total) | 21.9 [17.2, 24.4] | −0.63 (−0.81 to −0.36) | 19.2 [16.1, 22.1] | 24.4 [18.9, 26.9] | 0.013 |
| Plasma (unbound) | 18.5 [14.4, 21.1] | −0.66 (−0.82 to −0.39) | 15.9 [13.3, 18.7] | 21.1 [16.6, 23.3] | 0.007 |
| t1/2 (hours) | |||||
| ISF | 3.9 [2.8, 4.8] | 0.11 (−0.26 to 0.45) | 3.9 [2.7, 5.1] | 3.8 [3.0, 4.2] | 0.664 |
| Plasma (total and unbound) | 3.4 [2.6, 4.4] | 0.52 (0.20 to 0.74) | 3.8 [3.0, 4.8] | 3.0 [2.5, 3.6] | 0.088 |
| Vss (L), plasma | 37.7 [31.3, 44.6] | 0.87 (0.75 to 0.94) | 41.0 [38.4, 57.9] | 30.8 [27.9, 35.5] | <0.001 |
| CL (L/h), plasma | 7.2 [6.3, 9.3] | 0.21 (−0.16 to 0.53) | 8.2 [6.2, 10.8] | 7.0 [6.4, 8.2] | 0.170 |
| MRT (h), plasma | 5.0 [3.8, 6.3] | 0.47 (0.13 to 0. 71) | 5.7 [4.5, 6.9] | 4.4 [3.8, 5.4] | 0.079 |
| Tmax, ISF 30–60/60–90/>90 min (number of patients) | 17/3/10 | — | 7/3/5 | 10/0/5 | 0.252 |
| AUC0-8, (mg*h/L) | |||||
| ISF | 29.4 [23.5, 37.8] | −0.61 (−0.80 to −0.32) | 23.7 [20.2, 28.1] | 34.4 [29.4, 45.5] | 0.004 |
| Plasma (total) | 63.4 [52.8, 71.1] | −0.66 (−0.82 to −0.39) | 57.9 [45.4, 65.6] | 67.8 [61.5, 80.5] | 0.011 |
| Plasma (unbound) | 54.5 [45.6, 61.5] | −0.68 (−0.84 to −0.43) | 47.7 [39.7, 56.7] | 59.6 [51.7, 70.8] | 0.005 |
| AUC0–8 ISF/fAUC0–8 plasma | 0.53 [0.46, 0.65] | −0.28 (−0.58 to 0.09) | 0.53 [0.45, 0.55] | 0.62 [0.53, 0.68] | 0.080 |