Table 3.
Linezolid exposure in the interstitial fluid of subcutaneous adipose tissue and plasma relative to clinically relevant MIC values. Entries are the median [interquartile range] or estimate (95% confidence interval). The p-values refer to comparisons of the obese and non-obese groups. fAUC = area under the concentration–time curve of unbound concentrations; ISF = interstitial space fluid; MIC = minimal inhibitory concentration.
| All Patients (n = 30) |
Pearson’s Correlation Coefficient with Weight | Obese (n = 15) |
Non-Obese (n = 15) |
p-Value | ||
|---|---|---|---|---|---|---|
| MIC (mg/L) | ||||||
| fAUC24/MIC | ||||||
| ISF | 0.5 | 176.8 [125.4, 218.2] | −0.47 (−0.71 to −0.13) | 140.0 [105.6, 207.0] | 182.4 [165.4, 239.6] | 0.033 |
| 1 | 88.4 [62.7, 109.1] | 70.0 [52.8, 103.5] | 91.2 [82.7, 119.8] | |||
| 2 | 44.2 [31.3, 54.6] | 35.0 [26.4, 51.7] | 45.6 [41.3, 59.9] | |||
| 4 | 22.1 [15.7, 27.3] | 17.5 [13.2, 25.9] | 22.8 [20.7, 30.0] | |||
| plasma | 0.5 | 286.6 [220.8, 324.0] | −0.42 (−0.68 to −0.08) | 237.6 [199.8, 321.8] | 289.4 [250.0, 324.0] | 0.175 |
| 1 | 143.3 [110.4, 162.0] | 118.8 [99.9, 160.9] | 144.7 [125.0, 162.0] | |||
| 2 | 71.7 [55.2, 81.0] | 59.4 [49.9, 80.5] | 72.4 [62.5, 81.0] | |||
| 4 | 35.8 [27.6, 40.4] | 29.7 [25.0, 40.2] | 36.2 [31.3, 40.5] |