Table 1.

Characteristics of non-randomized human interventions studies.

Author, Year	Study Design	Geographic Setting	Study Population	Age (Years) and Gender	Intervention	Duration	Daily Dose Equivalent	Compliance
Ashraf, 2011 [25]	Before/after study	Birmingham, USA	14 obese post-menarchal female adolescents (13 African American, 1 Caucasian American), with serum 25OHD < 75 nmol/L Mean BMI (SD) in kg/m2: NR	Mean (SD) Pre-treatment: 14.9 (1.8) Post-treatment: 15.6 (1.7)	Vitamin D2 (ergocalciferol, orally, 50,000 IU), once per week	8 weeks	7142.8 IU	NR
				% Male: 0%
Javed, 2015 [26]	Before/after study	Rochester, USA	19 obese adolescents (89.5% non-Hispanic white), non-hypertensive, with serum 25OHD < 75 nmol/L Mean BMI (SD) in kg/m2: deficient: 21.2 (4.4); insufficient: 20.6 (3.6)	Range: 13–18 Mean (SD): 15.8 (1.7)	Vitamin D3 (cholecalciferol, 2 pills, 50,000 IU each; Total: 100,000 IU), once per month	12 weeks	3278.7 IU	100%
				% Male: NR
Khayyatzadeh, 2018 [27]	Before/after study	Mashhad and Sabzevar, Iran	940 healthy female adolescents, not taking medications or vitamin D supplements Mean BMI (SD) in kg/m2: 21.07 (4.2)	Range: 12–18 Deficient: 14.5 (1.53) Insufficient: 14.7 (1.51) Sufficient: 15.2 (1.53)	Vitamin D3 (cholecalciferol, 1 capsule, 50,000 IU), once per week	9 weeks	7142.8 IU	NR dropout rate: 4.8%
				% Male: 0%

25OHD: 25-hydroxyvitamin D; BMI: body mass index; SD: standard deviation; NR: not reported; IU: international units.