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. 2020 Apr 7;9(4):1049. doi: 10.3390/jcm9041049

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Diagnostic criteria for distinguishing primary from secondary hypogammaglobulinemia based in the differential B and T cell subset distribution in patients with primary immunodeficiency disorders (PID) as compared to patients with rheumatic disease and secondary hypogammaglobulinemia. (A) Heat map showing percentages of B and T cell subsets in all studied patients and highlighting their differential distribution. (B) Schematic representation of fulfilled diagnostic criteria (marked with blue) discriminating PID from secondary hypogammaglobulinemia. (C) Proposed diagnostic criteria for distinguishing primary from secondary hypogammaglobulinemia and cross tables showing all studied patients fulfilling or not fulfilling each time indicated criterion.