Table 2.
Hazard ratios (HR) and 95% confidence intervals (CI) of the association between initial misdiagnosis, sex, smoking, age at MS onset, BMI, age of the patients, and disease-modifying therapy (DMT) and reaching EDSS 4.
| Predictors of Reaching the Milestone | HR | CI (95%) | p |
|---|---|---|---|
| Misdiagnosis | |||
| - Not misdiagnosed (N = 75) | - | - | 1 |
| - Misdiagnosed (N = 53) | 0.81 | 0.46–1.42 | 0.46 |
| Sex | |||
| - Female (N = 84) | - | - | 1 |
| - Male (N = 44) | 0.49 | 0.26–0.92 | 0.03 |
| History of smoking | |||
| - No (N = 106) | - | - | 1 |
| - Yes (N = 22) | 1.41 | 0.71–2.82 | 0.33 |
| Age at MS onset | |||
| - <18 (N = 9) | 0.44 | 0.12–1.55 | 0.2 |
| - 18–50 (N = 114) | - | - | 1 |
| - >50 (N = 5) | 4.01 | 1.23–13.10 | 0.02 |
| BMI | |||
| - <18.5 (N = 8) | 1.87 | 0.79–4.46 | 0.16 |
| - 18.5–24.9 (N = 88) | - | - | 1 |
| - 25–29.9 (N = 22) | 1.20 | 0.58–2.46 | 0.63 |
| - ≥30 (N = 10) | 0.99 | 0.37–2.65 | 0.98 |
| Age | |||
| - 18–50 (N = 107) | - | - | 1 |
| - >50 | 0.99 | 0.47–2.07 | 0.98 |
| DMT | |||
| - Did not receive DMT (N = 70) | - | - | 1 |
| - Received DMT (N = 58) | 0.75 | 0.45–1.26 | 0.28 |