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. 2020 Apr 15;12(4):1090. doi: 10.3390/nu12041090

Table 1.

Compound summary table: an overview of the chemicals assessed in this study with structures and notes for each shown. Chemical structures were produced using ChemDrawTM.

Compound Structure Notes
Galantamine graphic file with name nutrients-12-01090-i001.jpg
  • Gold-standard for AChE inhibition [19]

  • Approved for the treatment of mild AD symptoms [19]

  • Poor side-effect profile

Flavan-3-ols Epicatechin Gallate graphic file with name nutrients-12-01090-i002.jpg
  • These flavanol compounds are found predominantly in green tea [23]

  • Antioxidative and anti-inflammatory properties identified [21]

  • Dietary intake of catechin polyphenols estimated to be 50 mg/day [24]

  • Blood–brain barrier permeability for these compounds is ~2.8% [25]

  • Consumption of two cups of green tea in 1 h is estimated to produce brain parenchyma concentrations of ~0.01 µM [25]

  • Low concentrations of EGCG in the brain have been reported to slow cognitive decline [23]

Epicatechin graphic file with name nutrients-12-01090-i003.jpg
Catechin graphic file with name nutrients-12-01090-i004.jpg
Epigallocatechin graphic file with name nutrients-12-01090-i005.jpg
Epigallocatechin Gallate graphic file with name nutrients-12-01090-i006.jpg