Table 1.
Levels of secreted cytokines and intracellular cytokines.
| Secreted Cytokines | Positive Control | Recombinant sIFNAR2 | P |
|---|---|---|---|
| GM-CSF | 74.29 (36.41–123.41) | 0 (0–30.1) | <0.01 |
| IFN-γ | 286.41 (160.79–1119.49) | 100.91 (36.66–547.09) | <0.01 |
| IL-1β | 3.68 (2.28–6.33) | 0.52 (0–2.89) | <0.01 |
| IL-13 | 28.62 (16.95–43.87) | 4.98 (3.31–10.84) | <0.01 |
| IL-18 | 19.05 (9.27–39.25) | 0 (0–15.79) | <0.01 |
| IL-2 | 407.85 (226.78–751.98) | 70.33 (31.82–92.4) | <0.01 |
| IL-4 | 23.24 (12.48–41.05) | 0 (0–0) | <0.01 |
| IL-6 | 181.26 (124.48–280.64) | 126.23 (32.47–204.91) | <0.01 |
| TNF-α | 146.03 (87.17–230.89) | 107 (59.46–179.44) | <0.01 |
| IL-10 | 4.33 (2.68–5.81) | 0 (0–0) | <0.01 |
| IL-17 | 9.46 (4.28–16.37) | 0 (0–0) | <0.01 |
| IFN-α | 0.55 (0–1.01) | 1.25 (0.23–2.81) | ns |
| IL-1α | 0.65 (0–1.09) | 0.6 (−0.81–1.15) | ns |
| Eotaxin | 1.66 (1.06–1.97) | 0.67 (0.03–0.89) | <0.01 |
| IL-8 | 1632.76 (899.79–3879.95) | 192.61 (−757.7–553.58) | <0.01 |
| IP-10 | 1632.61 (900.96–3877.33) | 191.59 (−757.85–552.85) | <0.01 |
| MIP-1α | 154.84 (−12.54–313.45) | 118.97 (59.33–187.69) | ns |
| MIP-1β | 730.09 (408.43–1047.2) | 432.29 (300.74–528.52) | <0.01 |
| Rantes | 21.73 (16.37–55.69) | 49.1 (−7.98–90.23) | ns |
| Intracellular Cytokines | Positive Control | Recombinant sIFNAR2 | P |
| IL-17 | 0.2 (0.2–0.3) | 0.1(0.1–0.2) | <0.01 |
| IFN-γ | 13.4 (7.3–17.37) | 8.1 (3.57–10.25) | <0.01 |
| TNF-α | 1.5 (0.42–0.07) | 1.8 (0.9–5.2) | ns |
Levels of normalized secreted cytokines (pg mL−1) and intra-cellular cytokines expressed as a % of cell expressing the cytokine. Data are medians and interquartile ranges. The Wilcoxon Rank test was used to compare the effect of recombinant sIFNAR2 with the positive control.