Table 4.
Adjusted associations of the changes in sphingolipids with changes in BMI and A1c *.
| Metabolites | BMI | A1c | ||
|---|---|---|---|---|
| β | p | β | p | |
| C16Cer | 0.65 | 0.068 | −0.04 | 0.419 |
| C18Cer | 0.97 | 0.006 | 0.05 | 0.302 |
| C16dhCer | 0.57 | 0.076 | 0.05 | 0.284 |
| C18dhCer | 0.58 | 0.033 | 0.11 | 0.003 |
| Sphingosine | 0.01 | 0.953 | 0.08 | 0.037 |
| S1P | −0.04 | 0.882 | 0.09 | 0.020 |
| C16SM | 0.31 | 0.414 | −0.02 | 0.594 |
| C18SM | 0.52 | 0.116 | 0.03 | 0.468 |
* Mixed-effect linear regressions are adjusted for age and sex. Levels of metabolites are standardized. Standardized β coefficients were presented. Abbreviations: BMI, body mass index; C16Cer, N-palmitoyl-sphingosine (d18:1/16:0); C18Cer, N-stearoyl-sphingosine (d18:1/18:0); C16dhCer, N-palmitoyl-sphinganine (d18:0/16:0); C18dhCer, N-stearoyl-sphinganine (d18:0/18:0); S1P, sphingosine 1-phosphate; C16SM, palmitoyl sphingomyelin (d18:1/16:0); C18SM, stearoyl sphingomyelin (d18:1/18:0).