Figure 4.

Effect of SCS on body weight and food intake in HCT-116 xenograft tumor mice model. Colon cancer HCT-116 cells were injected into BALB/c nude mice to develop the CRC model, while the control group was injected with normal saline. After 3 weeks, mice received an intragastric administration of different doses (100, 200, and 400 μg/g/day) of SCS (spine) and 5-FU (100 μg/g/day) as a positive control for 4 weeks. (A) Diagram of the experimental design, (B) body weight, (C) food intake. All results are expressed as mean ± SEM (n = 10). **** indicates p < 0.0001 as compared to every other group.