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. 2020 Apr 22;9(4):1195. doi: 10.3390/jcm9041195

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Mechanisms of action of CD38−directed monoclonal antibodies. The figure displays a multiple myeloma cell expressing CD38, with the most important mechanisms of action of the CD38−directed monoclonal antibodies. Abbreviations: ADCP: antibody-dependent cell-mediated phagocytosis; CDC: complement-dependent cytotoxicity; ADCC: antibody-dependent cell-mediated cytotoxicity; MoAb: monoclonal antibody; PCD: programmed cell death; MAC: membrane attack complex.