Figure 2.

Apulian EVO cultivars treatment reduces (A) body weight loss, (B) rectal bleeding and (C) intestinal permeability in DSS-treated mice. Mice were treated with Ogliarola, Cima di Mola, Coratina, Peranzana EVO and placebo by oral gavage starting a day prior to DSS administration through 10th day. (A) Percentage of body weight variance during DSS treatment, (B) visible rectal bleeding score, (C) In vivo intestinal permeability measurement after DSS-induced intestinal inflammation in C57Bl/J6 mice. All values represent means ± SD. Differences between means were tested for significance using 1-way ANOVA followed by the Bonferroni test (* p < 0.05).