Table 1.
Patient’s characteristics between the pre-dialysis and maintenance hemodialysis (HD) groups.
| Pre-dialysis (n = 37) | Maintenance HD (n = 7) | p Value | |
|---|---|---|---|
| Sex (Male/Female) | 22/15 | 5/2 | 0.132 |
| Age (years) | 71.4 ± 11.6 | 65.7 ± 7.8 | 0.222 |
| Classifications of RPGN | |||
| Immune complex CGN | 33 (89.2%) | 1 (14.3%) | |
| Pauci-immune CGN | 4 (10.8%) | 2 (28.6%) | |
| Anti-GBM CGN | 0 (0%) | 4 (57.1%) | |
| Immunosuppressive therapy | |||
| Pulse corticosteroids | 29/8 | 6/1 | 0.557 |
| Cyclophosphamide | 13/24 | 0/7 | 0.069 |
| Plasma exchange | 0/37 | 3/4 | 0.003 |
| White blood cell count (103/μL) | 10.2 (4.9–23.5) | 6.2 (4.7–12.4) | 0.037 |
| Neutrophil count (103/μL) | 8.5 (3.6–22.1) | 4.6 (3.3–8.4) | 0.012 |
| Lymphocyte count (103/μL) | 1.17 ± 0.59 | 1.31 ± 0.43 | 0.550 |
| Platelet count (103/μL) | 327 (98–808) | 189 (117–269) | 0.015 |
| Creatinine (mg/dL) | 2.80 ± 2.01 | 8.74± 1.80 | <0.001 |
| eGFR (mL/min/1.73 m2) | 27.3 ± 21.2 | 5.4 ± 2.0 | <0.001 |
| CRP (mg/dL) | 5.0 (0–24.8) | 4.0 (0.4–26.9) | 0.987 |
| ESR (mm/h) | 99 (10–140) | 111 (62–134) | 0.771 |
| MPO-ANCA (U/mL) | 166 (0–860) | 0 (0–2440) | 0.109 |
| PR3-ANCA (U/mL) | 0 (0–35.8) | 0 (0–0) | 0.308 |
| anti-GBM antibody (U/mL) | 0 (0–0) | 42.3 (0–858.0) | <0.001 |
| NLR | 8.2 (2.0–32.0) | 3.9 (2.8–8.4) | 0.019 |
| PLR | 265.7 (82.9–2255.0) | 126.0 (107.1–269.0) | 0.008 |
Data are presented as the mean ± standard deviation, median (range), or number (%). HD—hemodialysis; RPGN—rapidly progressing glomerulonephritis; CGN—crescentic glomerulonephritis; eGFR—estimated glomerular filtration rate; CRP—C-reactive protein; ESR—erythrocyte sedimentation rate; MPO—myeloperoxidase; ANCA—anti-neutrophil cytoplasmic antibody; PR3—proteinase 3; GBM—glomerular basement membrane; NLR—neutrophil-to-lymphocyte ratio; PLR—platelet-to-lymphocyte ratio.