. 2020 Apr 24;9(4):1239. doi: 10.3390/jcm9041239

Table 4.

Levels of Evidence and degrees of recommendation of the therapeutic physical exercise to reduce the adverse effects of breast cancer treatment, shown in the clinical practice guidelines (CPGs).

CPG	Doyle, C [13]	Rooney, M [14]	Manchon, P [15]	Murray, N [16]	Gradishar, WJ [17]	Harris, SR [18]	Greenlee, H [19]	Komoike, Y [20]	Runowicz, CD [21]	Paluch- Shimon, S [22]	Greenlee, H [23]	Senkus, E [24]
Treatment Aim	Doyle, C [13]	Rooney, M [14]	Manchon, P [15]	Murray, N [16]	Gradishar, WJ [17]	Harris, SR [18]	Greenlee, H [19]	Komoike, Y [20]	Runowicz, CD [21]	Paluch- Shimon, S [22]	Greenlee, H [23]	Senkus, E [24]
Mortality reduction	D **
Recurrence risk reduction	C *				A ^†
Increase quality of life	B ^†	A *
Pain reduction							B **		A **
Fatigue reduction	A **	B ^†				C **			A **		B **
Lymphedema reduction	B ^†					D ^†			B **
Musculoskeletal changes reduction									B **
Increase in range of movement of the shoulder								A **
Reduction of body weight alterations	A ^†	A ^†							B ^†			B *
Reduction of bone alterations	D ^†					D			A ^†	C ^†
Reduction of gastrointestinal disorders	**		*
Hot flashes reduction					D ^†
Neuropathy reduction									C *
Stress							B *
Depression		B ^†					B *				B *	*
Anxiety							B *				B *	*

* Very recommendable, ** Moderately recommendable, ^† Controversy.