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. 2020 Apr 1;12(4):973. doi: 10.3390/nu12040973

Figure 1.

Figure 1

Diminished vitamin D receptor (VDR) expression in damaged intestinal resections from Crohn’s disease (CD) patients. (a) A representative Western blot image of VDR protein in lysates of total mucosa from control (n = 8) and from CD patients (n = 10). The graph shows VDR protein expression vs. Glyceraldehyde 3-phosphate dehydrogenase (GAPDH) represented as fold induction vs. control mucosa. (b) mRNA expression (expressed as fold induction vs. control) of different genes vs. β-actin in total mucosa from control (n = 5) and CD patients (n = 10). In (a) and (b), bars in graph represent mean ± s.e.m. and significant differences vs. the control group are shown by * p < 0.05. (c) Representative Western blot from lysates of epithelial cells isolated from intestinal tissue of controls (n = 4) and CD patients (n = 4). Graph shows protein expression vs. GAPDH represented as fold induction vs. control. (d) Representative images showing VDR immunostaining in the mucosa of control and CD patients. (e) A representative Western blot image of VDR protein in lysates of total mucosa from CD patients with a stenotic (B2, n = 2) or penetrating (B3, n = 3) behavior. The graph shows VDR protein expression vs. GAPDH represented as fold induction vs. B2-CD.