NTDs	Neglected Tropical Diseases;
WHO	World Health Organization;
HTS	High-Throughput Screening;
FDA	Food and Drug and Administration;
HAT	Human African Trypanosomiasis;
DALY	Disability Adjusted Life Year;
NECT	Nifurtimox-Eflornithine Combination Therapy;
CNS	Central Nervous System;
ODC	Ornithine Decarboxylase;
NTR-1	type 1 nitroreductase;
PKDL	Post-Kala-azar Dermal Leishmaniasis;
AmpB	Amphotericin B;
ACT	Artemisinin-based Combined Therapies;
DNDi	Drugs for Neglected Diseases Initiative;
MMV	Medicine for Malaria Venture;
NGOs	Non-Governmental Organizations;
NCI	National Cancer Institute;
NPNPD	Program for the Discovery of Natural Products;
QSAR	Quantitative Structure-Activity Relationship;
CRK12	Cdc2-related kinase 12;
PTR1	Pteridine Reductase 1;
DHFR-TS	bifunctional Dihydrofolate Reductase-Thymidylate Synthase;
HCS	High Content Screening;
CCD	charge-coupled device;
SI	Selective Index;
LTopIB	Leishmania DNA topoisomerase IB.