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. 2020 Apr 13;18(4):210. doi: 10.3390/md18040210

Figure 1.

Figure 1

Recognizing aplykurodin A as a repressor of Wnt/β-catenin signaling. (A) The structure of aplykurodin A. (B,C) Inhibition of β-catenin responsive transcription (CRT) by aplykurodin A. After incubation of HEK293 reporter cells with either DMSO or aplykurodin A (20 and 40 μM) in the presence of Wnt3a-CM for 15 h, firefly luciferase (FL) (B) and HEK293-secreted alkaline phosphatase (SEAP) (C) activities were determined. These results represent the mean ± S.D. of three independent experiments. * p < 0.05 and ** p < 0.01, compared with the Wnt3a-CM-treated control group.