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. 2020 Apr 10;12(4):1042. doi: 10.3390/nu12041042

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Inhibitory effects of EGCG on canonical pathways in MDSCs in vitro. Activity of Arg-1 (A) and concentration of NO (B) in supernatant significantly decreased in EGCG treatments compared to control group. (C) The mRNA levels of Arg-1 were significantly reduced in MDSCs after EGCG treatment (D). No significant difference was found between EGCG and control groups on the mRNA levels of iNOS. (E,F) The production of ROS was reduced by EGCG treatments. (G,H) The mRNA levels of p47-phox and gp91-phox in MDSCs significantly decreased when treated with 5–10 μg/mL of EGCG. (I) The phosphorylated NF-κB and STAT3 were determined by Western blot. The mRNA levels of IL-6 (J), IL-10 (K), TGF-β (L), GM-CSF (M) decreased in MDSCs after 6 h-EGCG treatment. Data are presented as mean ± SEM. *, p < 0.05; **, p < 0.01; ***, p < 0.001.