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. 2020 Apr 10;12(4):1047. doi: 10.3390/nu12041047

Figure 4.

Figure 4

Blood percentages of (A) CD4+T-cell subsets including Th1, Th2, Th17, regulatory T (Treg) cell distributions, and the Th1/Th2 and Th17/Treg ratios. NC, normal control group; SH, sham group; SS12, septic saline group sacrificed at 12 h after cecal ligation and puncture (CLP); SA12, septic arginine (Arg) group sacrificed at 12 h after CLP; SS24, septic saline group sacrificed at 24 h after CLP; SA24, septic Arg group sacrificed at 24 h after CLP. (B) CD4+T-cell subsets and the Th1/Th2 and Th17/Treg ratios in sepsis groups with an inducible nitric oxide synthase (iNOS) inhibitor. SSL12, SS12 group with iNOS inhibitor; SAL12, SA12 with the iNOS inhibitor; SSL24, SS24 with the iNOS inhibitor; SAL24, SA24 with the iNOS inhibitor. Percentages of Th1 (interferon-γ-expressing cells), Th2 (interleukin-4-expressing cells), and Th17 cells (interleukin-17A-expressing cells) among CD4+ lymphocytes were measured. Treg cells are presented as a percentage of CD25+Foxp3+ cells among CD4+ lymphocytes. Data were analyzed using a one-way ANOVA with Tukey’s post hoc test and are presented as the mean ± SD. n = 8 for each group. # Significantly differs from the NC group (p < 0.05). * Significantly differs from the SS group at the same time point (p < 0.05).