Table 3.
IC50 values (µM) of the compounds tested in MDA-MB-231 cells for NF-κB inhibition and inhibition of cell viability. a
| Compound | NF-κB inhibition | Cell viability inhibition |
|---|---|---|
| Falconensin O (1) | 15.7 ± 0.7 | > 200 |
| Falconensin A (3) | 53.2 ± 21.4 | 89.7 ± 9.1 |
| Falconensin M (4) | 56.5 ± 8.3 | > 200 |
| Falconensin N (5) | 71.0 ± 7.3 | > 200 |
| Falconensin H (6) | 72.0 ± 28.1 | > 400 |
| Falconensin Q (7) | 11.9 ± 2.1 | > 200 |
| Falconensin R (8) | 14.6 ± 1.7 | 126.8 ± 5.4 |
| Falconensin S (9) | 20.1 ± 5.6 | > 200 |
| Falconensin I (11) | 19.5 ± 2.5 | > 400 |
aAverage IC50 of at least three individual experiments ± SD tested in the concentration range of 400 µM to 0.78 µM (3, 6, and 11) and 200 µM to 0.78 µM (1, 4, 5, 7, 8, and 9) in a two-fold serial dilution.