Table 2.
Twelve-month change from baseline in functional outcome measures for each study group.
| Outcomes | Healthy Ageing Mean (SD); n |
iAMD with no SDD Mean (SD); n |
iAMD with SDD Mean (SD); n |
||||||
|---|---|---|---|---|---|---|---|---|---|
| Baseline | 12 Months | p Value | Baseline | 12 Months | p Value | Baseline | 12 Months | p Value | |
| BCVA (ETDRS letters) | 87.1 (6.5); 12 | 85.7 (6.4); 12 | 0.356 | 84.8 (7.6); 15 | 85.7 (6.6); 15 | 0.456 | 81.6 (3.7); 8 | 83.0 (3.9); 8 | 0.211 |
| LLVA (ETDRS letters) | 73.5 (6.0); 12 | 70.4 (6.2); 12 | 0.182 | 70.8 (8.1); 15 | 67.2 (9.1); 15 | 0.005 | 68.1 (6.3); 8 | 65.9 (8.7); 8 | 0.188 |
| LLD (ETDRS letters) | 13.6 (3.7); 12 | 15.3 (4.3); 12 | 0.363 | 14.0 (5.5); 15 | 18.5 (6.3); 15 | 0.006 | 13.5 (5.9); 8 | 17.1 (8.3); 8 | 0.050 |
| Scotopic Thresholds (dB) | 56.18 (2.94); 12 | 57.96 (1.75); 12 | 0.030 | 54.69 (4.59); 15 | 55.58 (6.20); 15 | 0.303 | 54.92 (4.39); 8 | 53.93 (4.64); 8 | 0.576 |
| RIT (minutes) | 9.35 (5.21); 7 | 5.59 (2.58); 7 | 0.031 | 14.92 (6.12); 8 | 13.24 (5.17); 8 | 0.438 | 20.00 (0.00); 5 | 19.21 (1.77); 5 | >0.999 |
| Photopic 28.3Hz flicker ERG amplitude (µV) | 14.21 (5.92); 11 | 11.00 (4.21); 11 | 0.020 | 16.82 (7.74); 12 | 14.54 (6.30); 12 | 0.583 | 14.59 (4.67); 7 | 12.43 (5.88); 7 | 0.443 |
| Photopic 28.3Hz flicker ERG timing (ms) | 27.80 (1.28); 11 | 28.05 (0.82); 11 | 0.338 | 28.31 (1.34); 12 | 28.88 (1.28); 12 | 0.192 | 28.13 (1.23); 7 | 29.43 (1.14); 7 | 0.038 |
Means alongside the standard deviation (bracketed) values are shown. The p-values specified relate to the significance of the difference in mean change within study groups. iAMD = intermediate AMD; SDD = subretinal drusenoid deposits; BCVA = Best Corrected Visual Acuity; ETDRS = Early Treatment Diabetic Retinopathy Study; LLVA =l ow luminance visual acuity; LLD = low luminance deficit; RIT = rod intercept time; ERG = electroretinogram.