Table 5.
Association between various clinical parameters and miRNA gene polymorphisms in RPL patients.
| Patients | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Genotypes | Age (Years) | BMI (kg/m2) | Previous Pregnancy Losses (n) |
Mean Gestational Age (Weeks) |
aPTT (sec) | PLT (103/ul) | Folate (mg/ml) | Total Cholesterol (mg/dl) | Uric Acid (mg/dl) | BUN (mg/dl) | Creatinine (mg/dl) | Prolactin (ng/ml) | HDL (mg/dl) |
| (361) | (332) | (361) | (174) | (200) | (194) | (207) | (170) | (167) | (188) | (187) | (197) | (17) | |
| miR-25T>C | |||||||||||||
| TT | 32.7 ± 3.81 | 21.5 ± 4.34 | 3 ± 1.6 | 7.6 ± 2.08 | 32.5 ± 4.48 | 253.9 ± 54.71 | 14.8 ± 13.49 | 189.9 ± 51.96 | 3.9 ± 0.89 | 10.1 ± 2.77 | 0.7 ± 0.12 | 15.7 ± 12.79 | 55.1 ± 15.14 |
| TC | 31.9 ± 4.1 | 21.4 ± 2.53 | 3 ± 1.35 | 6.7 ± 1.37 | 31.4 ± 4.1 | 259.8 ± 60.24 | 13 ± 8.06 | 177.7 ± 38.61 | 3.6 ± 0.66 | 9.2 ± 2.32 | 0.7 ± 0.12 | 17 ± 14.61 | 86.2 ± 14.06 |
| CC | 33.8 ± 5.04 | 21.8 ± 2.31 | 2.8 ± 1.3 | 7.5 ± 1.78 | 32.6 ± 3.77 | 238.6 ± 54.21 | 12.5 ± 6.16 | 201.6 ± 63.85 | 3.6 ± 1.07 | 8.1 ± 2.37 | 0.6 ± 0.16 | 10.1 ± 0.54 | 63.3 ± 4.24 |
| P | 0.123 | 0.921 | 0.826 | 0.051 | 0.278 | 0.668 | 0.635 | 0.304 | 0.160 | 0.049 | 0.014 | 0.681 | 0.017 |
| miR-32C>A | |||||||||||||
| CC | 32.6 ± 3.91 | 21.4 ± 4.22 | 3.1 ± 1.54 | 7.5 ± 2.07 | 32.5 ± 4.56 | 256 ± 55.54 | 15 ± 13.13 | 185.1 ± 48.11 | 3.7 ± 0.86 | 9.9 ± 2.82 | 0.7 ± 0.12 | 16.2 ± 13.99 | 60.9 ± 17.86 |
| CA | 32.1 ± 3.97 | 21.9 ± 2.22 | 2.7 ± 1.48 | 6.9 ± 1.33 | 31.4 ± 3.69 | 252.1 ± 58.27 | 11.4 ± 6.62 | 194.4 ± 54.75 | 4 ± 0.79 | 10 ± 1.99 | 0.7 ± 0.13 | 14.8 ± 9.36 | 66.3 ± 27.37 |
| AA | 34 ± 5 | 20.1 ± 3.39 | 2 | 9 ± 1.41 | 33.7 ± 1.63 | 223 ± 31.11 | 15.1 ± 8.61 | 185 ± 9.9 | 3.2 ± 1.41 | 6.3 ± 2.34 | 0.6 ± 0.06 | N/A | N/A |
| P | 0.534 | 0.554 | 0.102 | 0.118 | 0.283 | 0.668 | 0.258 | 0.597 | 0.215 | 0.065 | 0.026 | 0.555 | 0.711 |
| miR-125aC>T | |||||||||||||
| CC | 32.9 ± 3.81 | 21.4 ± 3.38 | 3.1 ± 1.60 | 7.4 ± 2.05 | 32 ± 4.48 | 254.4 ± 52.57 | 14 ± 11.98 | 187.4 ± 48.49 | 3.8 ± 0.85 | 9.6 ± 2.67 | 0.7 ± 0.12 | 14.9 ± 10.98 | 65.9 ± 19.09 |
| CT | 31.8 ± 4.02 | 21.8 ± 5.15 | 2.9 ± 1.36 | 7.2 ± 1.53 | 33.2 ± 3.84 | 251.3 ± 60.4 | 15.3 ± 13.31 | 184.6 ± 50.46 | 3.8 ± 0.75 | 10.6 ± 2.67 | 0.7 ± 0.11 | 19.3 ± 18.1 | 51.2 ± 11.06 |
| TT | 31 ± 5.51 | 20.1 ± 4.25 | 2.9 ± 0.90 | 5 | 24.9 | 376 ± 66.47 | 12.9 ± 3.79 | 215.3 ± 76.14 | 4.9 ± 2.76 | 8.4 ± 2.32 | 0.7 ± 0.26 | 11.8 ± 3.9 | N/A |
| P | 0.040 | 0.473 | 0.537 | 0.409 | 0.068 | 0.008 | 0.794 | 0.578 | 0.905 | 0.062 | 0.891 | 0.286 | 0.130 |
| miR-222G>T | |||||||||||||
| GG | 32.8 ± 4.14 | 21.6 ± 3.25 | 3 ± 1.47 | 7.5 ± 1.97 | 31.8 ± 4.54 | 258.8 ± 58.07 | 14 ± 8.3 | 184.3 ± 50.45 | 3.9 ± 0.91 | 9.5 ± 2.62 | 0.7 ± 0.13 | 15.9 ± 12.11 | 59.1 ± 23.2 |
| GT | 32.4 ± 3.64 | 21.4 ± 4.83 | 3 ± 1.6 | 7.3 ± 1.98 | 32.8 ± 4.05 | 250.6 ± 52.18 | 15 ± 16.52 | 188.6 ± 49.03 | 3.6 ± 0.78 | 10.3 ± 2.72 | 0.7 ± 0.12 | 16.4 ± 14.96 | 65.4 ± 16.46 |
| TT | 31.3 ± 3.36 | 20.9 ± 2.15 | 3.6 ± 1.63 | 6.9 ± 1.25 | 33.6 ± 4.93 | 240.5 ± 60.32 | 10.4 ± 5.2 | 203.7 ± 40.95 | 3.8 ± 0.46 | 9.9 ± 2.92 | 0.7 ± 0.11 | 11.8 ± 3.66 | 51.8 ± 6.86 |
| P | 0.254 | 0.807 | 0.315 | 0.667 | 0.246 | 0.471 | 0.666 | 0.506 | 0.054 | 0.143 | 0.178 | 0.709 | 0.610 |
Data are presented as the mean ± standard deviation (SD). BMI; body mass index; PT, prothrombin time; aPTT, activated partial thromboplastin time; PLT, platelets; BUN, blood urea nitrogen. Significant P-values are marked in bold.