Table 3.
Subgroup analyses of simple and multiple linear regression model (estimated value (95% confidence interval)) for post index date of CP (post-ID CP) periods in CRS with/without nasal polyp group compared to control group according to age and sex.
| Linear Regression | ||||
|---|---|---|---|---|
| Simple † | p-Value | Multiple †‡ | p-Value | |
| Age 40–59 years old males | ||||
| Post-ID 1 y CP (n = 12,035, Mean ± SD = 0.46 ± 1.19 for CRS, Mean ± SD = 0.48 ± 1.31 for control) | ||||
| CRS total | −0.020 (−0.077 to 0.037) | 0.496 | −0.037 (−0.093 to 0.018) | 0.186 |
| Post-ID 2 y CP (n = 11,635, Mean ± SD = 0.54 ± 1.37 for CRS, Mean ± SD = 0.53 ± 1.43 for control) | ||||
| CRS total | 0.009 (−0.055 to 0.073) | 0.777 | −0.003 (−0.066 to 0.060) | 0.933 |
| Post-ID 3 y CP (n = 11,180, Mean ± SD = 0.63 ± 1.56 for CRS, Mean ± SD = 0.54 ± 1.40 for control) | ||||
| CRS total | 0.084 (0.017 to 0.150) | 0.013* | 0.074 (0.009 to 0.139) | 0.027 * |
| Post-ID 4 y CP (n = 10,565, Mean ± SD = 0.70 ± 1.62 for CRS, Mean ± SD = 0.61 ± 1.53 for control) | ||||
| CRS total | 0.097 (0.023 to 0.170) | 0.010* | 0.090 (0.017 to 0.163) | 0.015 * |
| Post-ID 5 y CP (n = 9705, Mean ± SD = 0.70 ± 1.60 for CRS, Mean ± SD = 0.65 ± 1.55 for control) | ||||
| CRS total | 0.055 (−0.022 to 0.133) | 0.164 | 0.044 (−0.033 to 0.121) | 0.263 |
| Age 40–59 years old females | ||||
| Post-ID 1 y CP (n = 6830, Mean ± SD = 0.44 ± 1.30 for CRS, Mean ± SD = 0.37 ± 1.07 for control) | ||||
| CRS total | 0.065 (−0.001 to 0.131) | 0.054 | 0.065 (0.002 to 0.129) | 0.043 * |
| Post-ID 2 y CP (n = 6690, Mean ± SD = 0.42 ± 1.11 for CRS, Mean ± SD = 0.41 ± 1.20 for control) | ||||
| CRS total | 0.010 (−0.061 to 0.080) | 0.788 | 0.008 (−0.061 to 0.078) | 0.817 |
| Post-ID 3 y CP (n = 6420, Mean ± SD = 0.50 ± 1.25 for CRS, Mean ± SD = 0.47 ± 1.32 for control) | ||||
| CRS total | 0.030 (−0.050 to 0.109) | 0.467 | 0.031 (−0.048 to 0.110) | 0.441 |
| Post-ID 4 y CP (n = 6095, Mean ± SD = 0.47 ± 1.20 for CRS, Mean ± SD = 0.49 ± 1.31 for control) | ||||
| CRS total | −0.018 (−0.098 to 0.063) | 0.669 | −0.015 (−0.095 to 0.064) | 0.705 |
| Post-ID 5 y CP (n = 5615, Mean ± SD = 0.55 ± 1.21 for CRS, Mean ± SD = 0.54 ± 1.40 for control) | ||||
| CRS total | 0.006 (−0.082 to 0.095) | 0.887 | 0.012 (−0.076 to 0.100) | 0.790 |
| Age ≥60 years old males | ||||
| Post-ID 1 y CP (n = 6215, Mean ± SD = 0.65 ± 1.56 for CRS, Mean ± SD = 0.57 ± 1.39 for control) | ||||
| CRS total | 0.083 (−0.005 to 0.172) | 0.064 | 0.079 (−0.005 to 0.163) | 0.066 |
| Post-ID 2 y CP (n = 5795, Mean ± SD = 0.64 ± 1.37 for CRS, Mean ± SD = 0.62 ± 1.49 for control) | ||||
| CRS total | 0.013 (−0.082 to 0.107) | 0.795 | 0.006 (−0.086 to 0.097) | 0.900 |
| Post-ID 3 y CP (n = 5225, Mean ± SD = 0.80 ± 1.74 for CRS, Mean ± SD = 0.63 ± 1.51 for control) | ||||
| CRS total | 0.172 (0.066 to 0.277) | 0.002 * | 0.165 (0.062 to 0.268) | 0.002 * |
| Post-ID 4 y CP (n = 4670, Mean ± SD = 0.81 ± 1.86 for CRS, Mean ± SD = 0.61 ± 1.52 for control) | ||||
| CRS total | 0.198 (0.085 to 0.312) | 0.001 * | 0.195 (0.083 to 0.307) | 0.001 * |
| Post-ID 5 y CP (n = 4030, Mean ± SD = 0.77 ± 1.83 for CRS, Mean ± SD = 0.68 ± 1.68 for control) | ||||
| CRS total | 0.086 (−0.046 to 0.217) | 0.203 | 0.088 (−0.041 to 0.218) | 0.182 |
| Age ≥60 years old females | ||||
| Post-ID 1 y CP (n = 4675, Mean ± SD = 0.42 ± 1.13 for CRS, Mean ± SD = 0.48 ± 1.23 for control) | ||||
| CRS total | −0.060 (−0.147 to 0.027) | 0.175 | −0.066 (−0.150 to 0.017) | 0.120 |
| Post-ID 2 y CP (n = 4410, Mean ± SD = 0.43 ± 1.08 for CRS, Mean ± SD = 0.46 ± 1.28 for control) | ||||
| CRS total | −0.030 (−0.121 to 0.062) | 0.523 | −0.033 (−0.122 to 0.056) | 0.464 |
| Post-ID 3 y CP (n = 3995, Mean ± SD = 0.51 ± 1.59 for CRS, Mean ± SD = 0.49 ± 1.28 for control) | ||||
| CRS total | 0.015 (−0.089 to 0.119) | 0.773 | 0.009 (−0.093 to 0.112) | 0.856 |
| Post-ID 4 y CP (n = 3670, Mean ± SD = 0.57 ± 1.58 for CRS, Mean ± SD = 0.49 ± 1.28 for control) | ||||
| CRS total | 0.089 (−0.020 to 0.198) | 0.109 | 0.089 (−0.019 to 0.196) | 0.106 |
| Post-ID 5 y CP (n = 3310, Mean ± SD = 0.63 ± 1.53 for CRS, Mean ± SD = 0.50 ± 1.25 for control) | ||||
| CRS total | 0.131 (0.019 to 0.243) | 0.022 * | 0.136 (0.025 to 0.247) | 0.017 * |
Abbreviations: CCI, Charlson comorbidity index; CP, chronic periodontitis; CRS, Chronic Rhinosinusitis. * Linear regression model, Significance at p < 0.05. † Models stratified by age, sex, income, and region of residence. ‡ A model adjusted for obesity, smoking, alcohol consumption, CCI scores, and pre index date of CP (pre-ID CP) for 2y.