Table 4.
Subgroup analyses of simple and multiple linear regression model (estimated value [95% confidence interval]) for post index date of CP (post-ID CP) periods in CRS with/without nasal polyp and control groups according to pre index date of CP (pre-ID CP) for 2 years.
| Characteristics | Linear Regression | |||
|---|---|---|---|---|
| Simple † | p-Value | Multiple †‡ | p-Value | |
| Pre-ID CP = 0 time for 2 years | ||||
| Post-ID 1 y CP (n = 19,090, Mean ± SD = 0.29 ± 0.91 for CRS, Mean ± SD = 0.29 ± 0.95 for control) | ||||
| CRS total | 0.005 (−0.029 to 0.038) | 0.780 | 0.006 (−0.028 to 0.039) | 0.746 |
| Post-ID 2 y CP (n = 18,530, Mean ± SD = 0.36 ± 1.04 for CRS, Mean ± SD = 0.35 ± 1.11 for control) | ||||
| CRS total | 0.013 (−0.027 to 0.052) | 0.525 | 0.015 (−0.024 to 0.054) | 0.455 |
| Post-ID 3 y CP (n = 17,665, Mean ± SD = 0.45 ± 1.32 for CRS, Mean ± SD = 0.38 ± 1.13 for control) | ||||
| CRS total | 0.064 (0.021 to 0.107) | 0.004 * | 0.065 (0.022 to 0.108) | 0.003 * |
| Post-ID 4 y CP (n = 16,715, Mean ± SD = 0.52 ± 1.43 for CRS, Mean ± SD = 0.41 ± 1.22 for control) | ||||
| CRS total | 0.108 (0.060 to 0.156) | <0.001 * | 0.111 (0.064 to 0.159) | <0.001 * |
| Post-ID 5 y CP (n = 15,410, Mean ± SD = 0.52 ± 1.29 for CRS, Mean ± SD = 0.47 ± 1.26 for control) | ||||
| CRS total | 0.050 (0.000 to 0.100) | 0.050 * | 0.052 (0.002 to 0.102) | 0.040 * |
| Pre-ID CP = 1 time for 2 years | ||||
| Post-ID 1 y CP (n = 4475, Mean ± SD = 0.51 ± 1.19 for CRS, Mean ± SD = 0.54 ± 1.27 for control) | ||||
| CRS total | −0.030 (−0.121 to 0.062) | 0.526 | −0.029 (−0.120 to 0.063) | 0.540 |
| Post-ID 2 y CP (n = 4270, Mean ± SD = 0.55 ± 1.25 for CRS, Mean ± SD = 0.60 ± 1.40 for control) | ||||
| CRS total | −0.052 (−0.154 to 0.051) | 0.321 | −0.051 (−0.153 to 0.051) | 0.329 |
| Post-ID 3 y CP (n = 4005, Mean ± SD = 0.67 ± 1.54 for CRS, Mean ± SD = 0.62 ± 1.50 for control) | ||||
| CRS total | 0.046 (−0.071 to 0.163) | 0.438 | 0.053 (−0.063 to 0.170) | 0.370 |
| Post-ID 4 y CP (n = 3665, Mean ± SD = 0.76 ± 1.68 for CRS, Mean ± SD = 0.66 ± 1.52 for control) | ||||
| CRS total | 0.095 (−0.031 to 0.220) | 0.139 | 0.097 (−0.029 to 0.223) | 0.130 |
| Post-ID 5 y CP (n = 3265, Mean ± SD = 0.83 ± 1.90 for CRS, Mean ± SD = 0.71 ± 1.63 for control) | ||||
| CRS total | 0.125 (−0.020 to 0.269) | 0.090 | 0.128 (−0.017 to 0.272) | 0.083 |
| Pre-ID CP ≥ 2 times for 2 years | ||||
| Post-ID 1 y CP (n = 6190, Mean ± SD = 1.08 ± 2.02 for CRS, Mean ± SD = 1.00 ± 1.82 for control) | ||||
| CRS total | 0.078 (−0.038 to 0.194) | 0.186 | 0.031 (−0.081 to 0.143) | 0.589 |
| Post-ID 2 y CP (n = 5730, Mean ± SD = 1.00 ± 1.76 for CRS, Mean ± SD = 0.98 ± 1.90 for control) | ||||
| CRS total | 0.017 (−0.104 to 0.138) | 0.780 | −0.023 (−0.142 to 0.097) | 0.710 |
| Post-ID 3 y CP (n = 5150, Mean ± SD = 1.14 ± 2.03 for CRS, Mean ± SD = 0.99 ± 1.88 for control) | ||||
| CRS total | 0.148 (0.017 to 0.279) | 0.027 * | 0.122 (−0.007 to 0.251) | 0.064 |
| Post-ID 4 y CP (n = 4620, Mean ± SD = 1.02 ± 1.90 for CRS, Mean ± SD = 1.01 ± 1.94 for control) | ||||
| CRS total | 0.003 (−0.137 to 0.142) | 0.970 | −0.013 (−0.152 to 0.126) | 0.853 |
| Post-ID 5 y CP (n = 3985, Mean ± SD = 1.09 ± 2.02 for CRS, Mean ± SD = 1.05 ± 2.04 for control) | ||||
| CRS total | 0.043 (−0.115 to 0.201) | 0.592 | 0.035 (−0.123 to 0.192) | 0.667 |
Abbreviations: CCI, Charlson comorbidity index; CP, chronic periodontitis; CRS, Chronic Rhinosinusitis. * Linear regression model, Significance at p < 0.05. † Models stratified by age, sex, income, and region of residence. ‡ A model adjusted for obesity, smoking, alcohol consumption, CCI scores, and pre-ID CP for 2y.