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. 2020 May 16;20:171. doi: 10.1186/s12935-020-01256-1

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Circ-MAT2B sponges miR-515-5p and upregulates HIF-1α. a The indicated three online tools predicting seven genes bound by miR-515-5p. b qRT-PCR analysis of seven gene levels in miR-515-5p-overexpressing AGS and MKN45 cells. c The luciferase reporter assay in AGS and MKN45 cells co-transfected with miR-515-5p mimics and the indicated luciferase HIF-1α-3`-UTR vector. d, e The expression level of HIF-1α in circ-MAT2B-depleted GC cells transfected with miR-515-5p inhibitors. f qRT-PCR analysis of HIF-1α in GC and normal tissues. g, h The indicated functional assays in circ-MAT2B knockdown GC cells transfected with HIF-1α-overexpreesing plasmid. **p < 0.01, ***p < 0.001